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Methotrexate is an antimetabolite medicine, as it affects cell metabolism. It can be prescribed for treating active rheumatoid arthritis, breast cancer, psoriasis, and some other conditions related to quick and abnormal growth of cells in the body. This medicine can be administered orally, as well as injected intramuscularly or intravenously. Methotrexate is most often given weekly, unless recommended otherwise by the doctor.